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It has been recognized as one of the leading gaming platforms for casinos despite its relative youth. Wolves is one of its latest releases, a 5-reel slot machine that has a high RTP and stunning graphics. Other notable titles include Wolf Gold and Chilli Heat. The goal of pragmatic trials is to simulate real-life situations and achieve the highest level of validity externally. Usually, they are commissioned by policymakers and practitioners in order to inform their decisions. They can also be a great method of determining the cause-effect relationship between the intervention and its effects. They should, however, not, be used to replace the need for explanation studies. The concept of pragmatism is controversial and there are questions about whether pragmatic trials should replace explanatory trials or complement them. 프라그마틱 정품 사이트 and Lellouch1 suggested a distinction between explanatory trials, which confirm the clinical or physiological hypothesis and pragmatic trials, which inform policy and practice decisions. They also proposed a framework for pragmatic trials, which they called PRECIS.2 This tool sought to define the features of a pragmatic trial which includes the recruitment process, the design and implementation of the intervention, as well as the follow-up. There is a growing increase in the number of pragmatic trials published. A recent Medline query that used the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatism. It is important to keep in mind that the majority of these studies were conducted in primary care settings.